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Indian Journal of Physiotherapy and Occupational Therapy - An International Journal
Year : 2018, Volume : 12, Issue : 4
First page : ( 161) Last page : ( 165)
Print ISSN : 0973-5666. Online ISSN : 0973-5674.
Article DOI : 10.5958/0973-5674.2018.00099.0

Effectiveness of cumin (Nigella sativa) extract on the decrease of Il-6 serum level and P65 placental NF-kB expression in preeclampsia mice

Zainiyah Hamimatus1, Hipni Rubiati2, Novian Ni Wayan3, Indrawan I Wayan Agung4

1Health Sciences Institute Ngudia Husada, Bangkalan, Madura, Indonesia

2Health Polytechnic Ministry of Health, Banjarmasin, South Kalimantan, Indonesia

3Obstetrics Academy, Denpasar, Bali, Indonesia

4Social Obstetrics and Gynecology Division Department of Gynecology Obstetrics, Saiful Anwar Hospital, Brawijaya Medical Faculty, Malang, East Java, Indonesia

Online published on 26 October, 2018.

Abstract

Analyzing the Effectiveness of Black Cumin (Nigella Sativa) extract on serum IL-6 levels and placenta NF-kB p65 expression in rats preeclampsia. The IL-6 method uses ELISA and NF-kB using immunohistochemistry. Results: IL-6 and NF-kB show a decreased level after being treated with a dose of 1500 mg/BB. Conclusion: Black cumin extract has the effect to reduce serum IL-6 levels and expression of p65 NF-kB placenta which will be used as a therapy for preeclampsia disorders.

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Keywords

Interleukin 6 (IL-6), Nuclear-kB Factor (NF-kB), Black cumin extract, Preeclampsia.

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