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Year : 2022, Volume : 46, Issue : 4
First page : ( 311) Last page : ( 321)
Print ISSN : 0250-4758. Online ISSN : 0973-970X. Published online : 2022  03.
Article DOI : 10.5958/0973-970X.2022.00053.0

Studies on hematological, serum biochemical and antioxidant effects in carbendazim induced toxicity and its amelioration with vitamin E in female chicken

Kiran K. Usha, Kumar A. Anand*, Srilatha C.1, Sreedevi B.2

Department of Veterinary Pathology, College of Veterinary Science, Sri Venkateswara Veterinary University, Tirupati-517 502, Andhra Pradesh, India

1Professor & University Head, Department of Veterinary Pathology, College of Veterinary Science, Proddatur

2Associate Dean, NTR CVSc., Gannavaram

*Address for Correspondence: Dr A. Anand Kumar, Department of Veterinary Pathology, College of Veterinary Science, Sri Venkateswara Veterinary University, Tirupati-517 502, Andhra Pradesh, India, E-mail: 7aakumar@gmail.com

Online Published on 03 February, 2023.

Received:  4  April,  2022; Accepted:  3  November,  2022.

Abstract

A total of 150 female chicks were randomly divided into six groups, maintained in ambient conditions with adlibitum normal feed and water. The experiment was carried out from 6th week to 12 weeks of age for 42 days. Group I (control) was fed with normal feed, group II and III with carbandazim (CBZ) @ 25 and 50 mg/kg BW respectively, group IV and V received CBZ @ 25 and 50 mg/kg BW respectively along with vitamin E @ 25 IU/kg of feed and group VI was fed with vitamin E @ 25 IU/kg of feed. Clinical signs such as dullness, decreased feed and water intake were observed in experimental groups. The haematological parameters in CBZ treated group III at higher dose revealed significant decrease in haemoglobin, total erythrocytes count and total leukocytes count. The serum biochemical parameters showed significant decrease in total protein, albumin and significant increase in the triglycerides, total cholesterol, SGPT and SGOT in CBZ treated groups. Significant decrease in the activities of CAT, SOD and GST of liver and kidney was observed in CBZ treated groups at higher dose. The study indicated that in amelioration groups slight improvement was noticed in comparison to CBZ treated groups in haematological, biochemical and antioxidant parameters. Thus, indicating the partial amelioration effect of vitamin E against Carbendazim toxicity.

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Keywords

Biochemical, Carbendazim, Haematological, Vitamin E.

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