Immunomodulatory Effect of Levamisole Therapy in Pre-parturient Dairy cows Mushtaq Mohsina1,*, Agrawal Rajesh2, Singh Rajiv3, Pande Nishi4, Bhavna5 Division of Veterinary Medicine Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology (SKUAST-J), R.S. Pura, Jammu-181102 (Jammu and Kashmir) 1Ph. D. Scholar, Department of Gynecology and Obstetrics, Military Dairy Farm, Satwari, Jammu 2Associate Professor, Department of Gynecology and Obstetrics, Military Dairy Farm, Satwari, Jammu 3Professor and Head, Department of Gynecology and Obstetrics, Military Dairy Farm, Satwari, Jammu 4Assistant Professor, Department of Gynecology and Obstetrics, Military Dairy Farm, Satwari, Jammu 5Veterinary Officer, Military Dairy Farm, Satwari, Jammu *Corresponding author. E-mail: mosu2011@gmail.com
Online published on 30 November, 2019. Abstract The study was undertaken in Holstein Friesian crossbred dairy cows (n=16) in late gestation. The cows were divided into two equal groups of eight animals each. Group-1 was administered with four doses of Levamisole on 35, 28, 21 and 14th day prior to parturition and Group-2 was control. Colostrum and blood samples were collected from both groups on calving day for colostrum and calving day as well as 28th day in milking for blood and analysed. Evaluation revealed significantly (P<0.05) lower plasma Malondialdehyde (MDA) levels and higher Glutathione peroxidase (GPx), Glutathione S transferase (GST) and Superoxide dismutase enzyme (SOD) activity in Levamisole treated group as compared to control group. Serum and colostrum total Ig levels in Levamisole treated groups were significantly (P<0.05) higher as compared to control groups. The study concluded that Levamisole therapy during late dry period has positive effect on immunity in dairy cows. Top Keywords Cow, dairy, levamisole, oxidative stress, immunoglobulin. Top |