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Research Journal of Pharmacy and Technology
Year : 2008, Volume : 1, Issue : 1
First page : ( 18) Last page : ( 21)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.

Development of RP-HPLC Method for Estimation of Carvedilol in Tablet Formulations

Singh Mahaveer1,*, Kashkhedikar S.G.1, Soni Love1, Garg Abhinav1, Gandhi Tripti2, Patel Amrish2

1Department of Pharmacy, Shri G.S. Institute of Technology and Science, Indore 452003, India

2Department of Analytical Development, Torrent Pharmaceutical Ltd., Ahmedabad, India

*Corresponding Author E-mail: mahaveer2singh@gmail.com

Abstract

A simple and sensitive reverse phase high performance liquid chromatographic method has been developed for estimation of Carvedilol in pharmaceutical formulation. The quantification was carried out using Inertsil C8 150 mm* 4.6mm, 5μm column in isocratic mode. The mobile was made up of buffer and Acetonitrile in the ratio of 65:35 (v/v). Potassium dihydrogen phosphate was used for preparation of buffer. The detection was carried out at 240nm and linearity was found to be in the range of 2 to 10 μg/ml. The method was duly validated as per ICH guidelines.

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Keywords

RP-HPLC, Carvedilol, pharmaceutical dosage form Acetonitrile.

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