(34.231.21.123)
Users online: 4305     
Ijournet
Email id
 

Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 12
First page : ( 5385) Last page : ( 5393)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00983.6

Synthesis, Medicinal Applications and QSAR Study of Benzimidazole, Thiophene, Piperazine derivatives for Antimycobacterial, Antibacterial, Antifungal Activities

Sachin C Kale1,*, Ashutosh Upadhayay1, Kale M.K2

1M.J.R.P. University, Jaipur, Rajasthan, India

2K.G.R.D. College of Pharmacy and Research Institute, Karjat, Raigad. Maharashtra, India

*Corresponding Author E-mail: sachin_kale83@rediffmail.com

Online published on 18 May, 2019.

Abstract

Benzimidazole, Thiophene, Piperazine derivatives regarded as an important heterocyclic motif that exhibits a wide range of Medicinal applications including Antimycobaterial, antibacterial, Antifungal, Anti-HIV's. In the view of their wide ranging activities the synthesis of benzimidazole, Thiophene, Piperazine and its derivatives remain a primary focus for synthetic chemistry Communities. The association of HIV and TB infection is a serious problem. TB is caused by bacilli belonging to the Mycobacterium tuberculosis. In the Review of Literature it was observed that various method's are available for synthesis of Benzimidazole, Thiophene, piperazine derivatives. Thirty seven compounds were synthesized and the structures of these compounds were established by means of IR, 1H-NMR, C13 NMR and elemental analysis. All compounds were evaluated for antibacterial, antifungal and antitubercular activities. Most of the compounds have shown significant antibacterial, antifungal and antitubercular activity when compared with the standard drug. QSAR Study will be done as per the need of Compound.

Top

Keywords

Benzimidazole, Piperazine, Thiophene, QSAR, TB.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
389,940,927 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.