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Research Journal of Pharmacy and Technology
Year : 2022, Volume : 15, Issue : 12
First page : ( 5512) Last page : ( 5516)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.52711/0974-360X.2022.00930

Formulation and Characterization of Buccal Patches of Oxaceprol

Kunal V Bhambar1,*, Rajendra S. Bhambar2, Avinash B. Darekar3, Pravin P. Gadakh4, Rutuja Aher5

1MGV’s Pharmacy College, Panchavati, Nashik, Maharashtra, India.

2MGV’s Pharmacy College, Panchavati, Nashik, Maharashtra, India.

3KVN Naik SPS Institute of Pharmaceutical Education and Research, Canada Corner; Nashik.

4MGV’s Pharmacy College, Panchavati, Nashik, Maharashtra, India.

5Modern College of Pharmacy, Dehu Alandi Road Borhadewadi, Moshi, Pune.

*Corresponding Author E-mail: kunalbhambar@gmail.com

Online Published on 06 March, 2023.

Abstract

Background

Oxaceprol is an anti-inflammatory and antirheumatic agent. Buccal route has advantage over conventional mode of drug administration. It avoids hepatic first pass metabolism and improve patient compliance. The main objective of the present study is to formulate and evaluation of buccal patches of Oxaceprol to overcome drawbacks of conventional dosage forms. Buccal patches were prepared by solvent-casting method using HPMC K-15 and PEG as plasticizer. Oxaceprol was initially characterized for its preliminary studies such as organoleptic properties, melting point, solubility, UV Spectroscopy, and FTIR studies. Drug-excipients compatibility was confirmed by FTIR, DSC and assay of drug content. The formulations were prepared and evaluated for parameters like physical appearance, thickness, weight uniformity, % moisture loss, folding endurance, drug content uniformity. All prepared patches of drug were smooth and elegant in appearance. No visible cracks were observed. All formulations were uniform in weight, thickness, and drug content. The folding endurance was increased with an increased in polymer concentration. In vitro drug release of F6 batch was 93.78% at the end 8 hr. Oxaceprol buccal patches showed enhanced the bioavailability. Release exponent n value obtained from Kors Meyer- Peppa’s equation was within 0.5 -1.0 which indicates anomalous release.

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Keywords

Oxaceprol, HPMC, Buccal Patches, PEG.

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