Biological Properties of Gynura procumbens Leaves Extract to MDA Levels and Antioxidant Activities in Liver of Mice Sugiharto1,2,*, Wibowo Anjar Tri1,2, Zubaidah Ummi1, Savitri Annisa Dwi1, Faukib Muhammad Sidqon1, Salsabila Navy Safira1, Manuhara Yosephine Sri Wulan1,2,** 1Department of Biology, Faculty of Science and Technology, Airlangga University, Surabaya, Indonesia. 2Biotechnology of Tropical Medicinal Plants Research Group, Faculty of Science and Technology, Airlangga University, Surabaya, Indonesia. *Corresponding Author E-mail: sugiharto@fst.unair.ac.id
**yosephine-s-w-m@fst.unair.ac.id
Online Published on 06 March, 2023. Abstract The objective of our research was to the evaluated biological activities of G. procumbens leaves methanol extract (GLME) for the hepatoprotective against cadmium (Cd) toxicity in mice. Research was performed using twenty five healthy male mice, which were grouped into five treatments: P1 (control), P2 (Cd-100mg/L), P3 (GLME-100mg/L+Cd-100mg/L), P4 (GLME-200mg/L+Cd-100mg/L), P5 (GLME-300mg/L+Cd-100mg/L). The results showed GLME contain phenolic and flavonoids compound by total phenolic content (TPC) and total flavonoid content (TFC) assay, they were strongly correlated with antioxidant activities. In this study, it was also known that Cd exposure increasing malondialdehyde (MDA) level and decreasing of superoxide dismutase (SOD) and catalase (CAT) activities in liver homogenates compared to control significantly. This is in line with a decreased in the number of normal cells and slightly an increased in damage cells in the histological hepatic cells. Administration of GLME can prevent liver cell damage due to Cd treatment by increasing the number of histological normal cells and the activities of SOD and CAT enzyme and reducing the level of MDA in liver homogenates. The best treatment of GLME was 100mg/L. Top Keywords Antioxidant activity, Gynura procumbens, Health care, Hepatoprotective, MDA. Top |