A Review on Synthetic Approaches and Activities of 1, 2, 4-Triazoles Singh Mahavir1, Sawarkar H.1,*, Shrivastav Birendra1, Bakal1 Department of Pharmaceutical Chemistry, School of Pharmacy, Jaipur National University, Jaipur. 1Department of Pharmaceutical Chemistry, Dr. Rajendra Gode Institute of Pharmacy, Amravati. *Corresponding Author E-mail: vedanshumlv56@gmail.com
Online Published on 06 March, 2023. Abstract 1, 2, 4-Triazoles and their derivatives have a distinct place in the field of medicinal and pharmaceutical chemistry. These are used as lead compounds for the synthesis of numerous heterocyclic compounds which possess diverse biological activities and play pivotal roles. This review covers the latest literature and knowledge on the synthetic procedures for various triazoles derivatives, their activities and pharmacological applications. The synthetic routes of 1, 2, 4-triazole compounds as well as their pharmacological properties have been described. The review focuses intensively on two methods: cyclo-addition reaction in the syntheses of various 1, 5-dialky-1H-1, 2, 4-triazole derivatives from the reactive cumulenes with the nitrile precursors as well as the microwave irradiation method. Top Keywords 1, 2, 4-triazoles, Pharmacological properties, Synthetic routes. Top |