Nanohydroxyapatite-Chitosan Hydrogel Scaffold with Platelet Rich Fibrin and Buccal Fat Pad derived Stem Cell for Aggressive Periodontitis Treatment: A Narrative Review Saputra Gustiadi1, Nugraha Alexander Patera2,3,4,*, Budhy Theresia Indah2, Rosari Fransisca Shancti3, Lestari Nur Aini Indah5, Sari Alifiya Afita5, Gheasani Afiqah5, Valensia Theodora5, Ramadhani Nastiti Faradilla4,6, Noor Tengku Natasha Eleena Binti Tengku Ahmad7,8, Nugraha Albertus Putera9, Nugraha Andreas Pratama10,11, Sosiawan Agung12 1Graduate Student of Immunology, Postgraduate School of Universitas Airlangga, Surabaya, Indonesia. 2Immunology Study Program, Postgraduate School of Universitas Airlangga, Surabaya, Indonesia. 3Orthodontics Department, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia. 4Graduate Student of Dental Health Science, Universitas Airlangga, Surabaya, Indonesia. 5Undergraduate Student, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia. 6Dentomaxillofacial Radiology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia. 7Malaysian Armed Forces Dental Officer, 609 Armed Forces Dental Clinic, Kem Semenggo, Kuching, Sarawak, Malaysia. 8Membership of Faculty of Dental Surgery, Royal College of Surgeon, Edinburgh University, United Kingdom. 9Undergraduate Student, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. 10Graduate Student of Clinical Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. 11Oral and Maxillofacial Surgery Resident, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia. 12Dental Public Health Department, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia. *Corresponding Author E-mail: alexander.patera.nugraha@fkg.unair.ac.id
Online Published on 06 March, 2023. Abstract Periodontal disease is oral health problem which attacks 20-50% of the global population. In Indonesia, 60% population suffers periodontal disease and become the second most common disease in the oral cavity. Aggressive periodontitis (AP) is one of periodontal disease, mainly attacks individual under 30 years-old, with rapid alveolar bone destruction. Bone graft implantation surgery is the current treatment for AP, but it is invasive and high risk infection. Nanohydroxyapatite-chitosan (nHPA-CS) hydrogel injectable scaffold is non-invasive treatment that contains bone mineral hydroxyapatite that derived from bovine bone and chitosan (CS) biopolymer with low immunogenicity. Platelet-Rich-Fibrin (PRF) contains huge amount growth factor which is biodegradable to human body. Buccal-Fat-Pad Stem-Cell (BFPSC) was chosen because it is easy to harvest and able to differentiate into mesenchymal lineage tissue. The aim of this narrative review is to describe the potential combination of nanohydroxyapatite-chitosan hydrogel scaffold, platelet-rich-fibrin, and buccal-fat-pad stem-cells for regenerating alveolar bone in aggressive-periodontitis patients. Data was obtained by literature study scientific research articles. In patients with AP, BFPSC can differentiate into osteoblast to improve osteogenesis, nHPA-CS scaffold creates host like tissue microenvironment to stimulate osteoinduction and osteoconduction activity of BFPSC, while PRF stimulates osteogenic differentiation and proliferation of BFPSC with insulin growth-factor, platelets derived growth-factor, transforming growth-factor, fibroblast growth-factor, vascular endothelial growth-factor. this combination increasing runt-related transcription-factor2, osterix, bone alkaline phosphatase, and controls pro-inflammatory cytokines such as interleukin-1beta (IL-1b) and tumor necrosis factor-alpha (TNF-a) so it can enhance bone regeneration and avoid bone destruction. The combination of nHPA-CS, PRF, BFPSC has the potential for alveolar bone regeneration in Aggressive-Periodontitis patients. Top Keywords Nanohydroxyapatite-chitosan hydrogel, Platelet rich fibrin, Buccal fat pad mesenchymal stem cells, Infectious disease, Medicine. Top |