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Research Journal of Pharmacy and Technology
Year : 2022, Volume : 15, Issue : 4
First page : ( 1549) Last page : ( 1554)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.52711/0974-360X.2022.00258

Flaxseed mucilage hydrogel based floating drug delivery system: Design and evaluation

Ramteke Shreya1, Haigune Naresh1, More Sachin2, Pise Shilpa3, Pise Ajay4, Kharwade Rohini5,*

1B.Pharm. Final Year Student, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, (MS), India

2Asst. Professor, Pharmacology DepartmentDadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, (MS), India

3Asst. Professor, Regulatory Affair DepartmentDadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, (MS), India

4Professor, Quality Assurance DepartmentDadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, (MS), India

5Asst. Professor, Pharmaceutic DepartmentDadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, (MS), India

*Corresponding Author E-mail: rohinismore1@gmail.com

Online Published on 08 June, 2022.

Abstract

Natural polymer-based plant polysaccharides and proteins have been most widely explored as an adjuvant in the dosage form formulation. Here we design a novel gastro-retentive floating tablet, based on a polysaccharide material from Flaxseed (Linum usitatissimum L.) for Domperidone. After oral administration; Domperidone showed good solubility in acidic pH but significantly reduced solubility in alkaline medium. So that to increase the absorption and bioavailability of Domperidone, it is necessary to increase the retention time in the upper part of the Gastrointestinal tract (GIT) by developing a floating sustained drug delivery system. The directly compressible floating tablets of domperidone were formulated using varying amount of hydroxypropyl methylcellulose K 100 M (HPMC K100 M), Carbopol 934 and Flaxseed mucilage. Hardness, friability, weight variation, thickness, disintegration time of tablet formulations were within acceptable limits. The overall results explained that the optimized formulation F5 prepared by the exact ratio of Flaxseed mucilage, HPMC K100 M, Carbopol, could be more efficient on floating and sustained release of Domperidone in the upper part of GIT as compared to the tablets prepared by using HPMC K100 M and Carbopol 934 only. These findings indicated that Flaxseed can be used to develop novel gastro-retentive sustained release drug delivery system with the double advantage of sustained drug release at the upper part of GIT.

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Keywords

Floating tablet, Flaxseed mucilage, Sustained release, Gastroretentive, Drug release kinetics.

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