Formulation, development and release enhancement of sustained release tablet of antidiabetic drug glipizide by the use of natural polymers Chauhan Sonia*, Mazumder Rupa**, Mishra Rakhi***, Mazumder Avijit****, Srivastava Nidhi***** Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida - 201306, Uttar Pradesh, India *Corresponding Author E-mail: soniya.chauhan012@gmail.com
**rupa_mazumder@rediffmail.com
***rakhi.misra84@rediffmail.com
****avijitmazum@yahoo.com
*****nidhi10feb@gmail.com
Online Published on 08 June, 2022. Abstract Background Modification in sustained release system is a newly developed area that has shown good control over the administration of drug by maintaining systemic concentrations. Objective The study was conducted to formulate a sustained release tablet of antidiabetic drug, glipizide, with improvement in patient's compliance. Methods Sustained release tablet of glipizide was prepared by using different concentration of natural polymers like guar gum, chitosan and xanthan gum as a release modifier by wet granulation method. The tablets had been analyzed by chemical and physical parameters. Drug and polymer interactions had been studied by FT-IR and in vitro drug release had been studied using rotating paddle dissolution apparatus. The release rate had been studied on different models in order to measure their release kinetics. Results Obtained FT-IR spectra interpreted no interaction of used natural polymers. Over a period of 12 hrs the maximum drug release was 98.66%. Conclusion The results of the study successfully revealed that the formulated sustained release tablet of glipizide could be formulated by use of natural polymers which could provide maximum drug release and this study could further be explored to formulate other doasage forms by using natural source polymers. Top Keywords Glipizide, Antidiabetic, Sustained release, Natural polymer, Wet granulation, Drug release, Guar gum, Chitosan, Xanthan gum. Top |