Synthesis, and antimicrobial evaluation of new hydrazone derivatives of (2,4-dinitrophenyl) hydrazine Sahib Halah A.*, Hadi Mohammed K., Abdulkadir Maadh Qusay Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad, Iraq *Corresponding Author E-mail: hala.abd@copharm.uobaghdad.edu.iq
Online Published on 08 June, 2022. Abstract In this work, novel compounds of hydrazones derived from (2,4-dinitrophenyl) hydrazine were synthesized. Benzamides derivatives and sulfonamides derivatives were prepared from p-amino benzaldehyde. Then these compounds were condensed with (2,4-dinitrophenyl) hydrazine through Imine bond formation to give hydrazones compounds. The compounds were characterized using FT-IR (IR Affinity-1) spectrometer, and 1HNMR analyses. The majority of the compounds have a moderate antimicrobial activity against “Gram -positive bacteria staphylococcus Aureus, and staphylococcus epidermidis, Gram-negative bacteria Escherichia coli, and Klebsiella pneumoniae, and fungi species Candida albicans” using concentrations of 250 µg\ml. Top Keywords (2,4-dinitrophenyl) hydrazine, Schiff base, Hydrazone, Amide, Sulfonamides, Antibacterial and Antifungal activity. Top |