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Research Journal of Pharmacy and Technology
Year : 2022, Volume : 15, Issue : 4
First page : ( 1743) Last page : ( 1748)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.52711/0974-360X.2022.00292

Synthesis, and antimicrobial evaluation of new hydrazone derivatives of (2,4-dinitrophenyl) hydrazine

Sahib Halah A.*, Hadi Mohammed K., Abdulkadir Maadh Qusay

Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad, Iraq

*Corresponding Author E-mail: hala.abd@copharm.uobaghdad.edu.iq

Online Published on 08 June, 2022.

Abstract

In this work, novel compounds of hydrazones derived from (2,4-dinitrophenyl) hydrazine were synthesized. Benzamides derivatives and sulfonamides derivatives were prepared from p-amino benzaldehyde. Then these compounds were condensed with (2,4-dinitrophenyl) hydrazine through Imine bond formation to give hydrazones compounds. The compounds were characterized using FT-IR (IR Affinity-1) spectrometer, and 1HNMR analyses. The majority of the compounds have a moderate antimicrobial activity against “Gram -positive bacteria staphylococcus Aureus, and staphylococcus epidermidis, Gram-negative bacteria Escherichia coli, and Klebsiella pneumoniae, and fungi species Candida albicans” using concentrations of 250 µg\ml.

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Keywords

(2,4-dinitrophenyl) hydrazine, Schiff base, Hydrazone, Amide, Sulfonamides, Antibacterial and Antifungal activity.

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