Estimation of Serum Fasting Insulin in Patients with Acne Vulgaris and Compares these Values with that in Controls Chaudhary Archana1, Singh Urender2, Sawhney MPS3, Karunanand Busi4, Anand Bhupinder Kaur5,*, Singh Marwaha Manvinder Pal6 1Associate Professor, Department of Environmental Science, Faculty of Science, SGT University, Gurugram, Haryana, India 2Additional Sr. Medical Officer, Civil Hospital, Bhiwani 3Professor, Department of Dermatology & Venereology, SSGT Medical College, Hospital and Research Institute, Gurugram, Haryana, India 4Professor, Department of Biochemistry, SSGT Medical College, Hospital and Research Institute, Gurugram, Haryana, India 5Professor, Department of Community Medicine, SSGT Medical College, Hospital and Research Institute, Gurugram, Haryana, India 6Classified Specialist Aerospace Medicine, Air Force Central Medical Establishment, New Delhi, India *Corresponding Author: Bhupinder Kaur Anand, Professor, Department of Community Medicine, SGT Medical University, Gurugram, Haryana, India Email: dr.medical.123@gmail.com
Online published on 26 September, 2019. Abstract Introduction Acne is a multifactorial inflammatory disease affecting the pilosebaceous follicles of the skin. Acne is a disorder resulting from the effect of hormones and other substances on the oil glands (sebaceous glands) and hair follicles present in the skin. The aim of this study was estimation of serum Fasting insulin in patients with acne vulgaris and compares these values with those in controls. Methodology This is the case control study which was carried out in the Departments of Biochemistry and Dermatology & Venereology of SGT Medical College Gurgaon. Fifty patients each of Mild (group I), Moderate (group II) and Severe Acne Vulgaris (group III) in age group 15–40 years were included as cases. Result In the present study, the level of serum insulin was significantly higher in moderate cases of acne as compared to controls. Therefore we suggest that insulin may also play an important marker for causing acne. Insulin stimulates the secretion of ovarian estrogen, androgen and progesterone which is consistent with our studies as increase in estrogen and testosterone has been also observed in moderate cases of acne. Conclusion Insulin was significantly higher in moderate cases as compared to controls. There by suggesting that insulin may play an important role to causation of acne. Top Keywords Insulin, acne vulgaris, multifactorial inflammatory disease. Top |