(44.200.169.91)
Users online: 5050     
Ijournet
Email id
 

Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2010, Volume : 2, Issue : 1
First page : ( 107) Last page : ( 110)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.

Enhancement of Dissolution Rate Studies on Solid Dispersion of Aceclofenac

Thotacherla S. Lakshmi*, Shamsunisha A. M., Sirisha Y., Valarmathi C., Senthilkumar K. L.,  Ezhilmuthu, Vasanthan A., Sumathy P.

Department of Pharmaceutics, Padmavathi College of Pharmacy, Dharmapuri (DT), Tamil Nadu

*Corresponding Author: Dr. K. L. Senthil Kumar Principal, Padmavathi College of Pharmacy, Dharmapuri (DT), Tamil Nadu. E-mail: klsenthilkumar1969@yahoo.co.uk

Online published on 19 March, 2013.

Abstract

Aceclofenac is a Non-Steroidal Anti Inflammatory drug indicated for the relief of pain and inflammation, associated with rheumatoid arthritis, osteo arthritis, ankylosing, spondylitis. The percentage of dissolution rate of drug released from pure Aceclofenac was obtained 26.48% in 180min. The aim of the study was to enhance the dissolution rate on solid dispersion of Aceclofenac by using PEG6000 as carrier in three different ratios such as ACF:PEG6000-1:1, 1:2 and 1:4 by fusion method or melting method. The percentage of drug release of Aceclofenac from solid dispersions ACF:PEG6000-1:1, 1:2 and 1:4 was 59.65%, 84.75%, 98.34% respectively in 180min. Aceclofenac from solid dispersions due to enhancing effect of PEG6000.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
733,017,293 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.