Identification of potential flavonoids against the spleen tyrosine kinase to treat psoriasis: In silico approach Pol Sagar1,*, Kadam Vilasrao2, Jagtap Sujata3, Bhosale Sampada2, Pawar Nita1, Gaikwad Ravindra4 1Bharati Vidyapeeth’s Institute of Pharmacy, CBD Belapur, Navi Mumbai, Maharashtra, 400614, India 2Bharati Vidyapeeth’s College of Pharmacy, CBD Belapur, Navi Mumbai, Maharashtra, 400614, India 3Bharati Vidyapeeth’s Institute of Pharmacy, Erandwane, Pune, Maharashtra, 411038, India 4Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, 416013 (MS), India *Corresponding Author E-mail: sagar.pol007@gmail.com
Online Published on 4 October, 2023. Abstract Now a day, phytochemicals are widely consideration for structure optimization programs which focuses on making more active and less toxic drug products. Psoriasis is an inflammatory, chronic, remitting and relapsing, genetically influenced skin disease. Variety of flavonoid structureswere used to find the potential molecules against the psoriasis. In this current study molecular docking studies were carried out to identify the flavonoids having good binding ability with the target protein of psoriasis. Docked ligands were subjected to identify the drug like properties using drug-likeness prediction. Findings suggested that 23 flavonoid structures may act against the psoriasis. Top Keywords Drug design, De novo design, Ligand system, Artificial intelligence, Machine learning. Top |