Formulation and Evaluation of Fast Disintegrating Tenoxicam Tablets and The Comparison with Marketed Product Chopade Swapnil S1,*, Gaikwad Esther1, Jadhav Avdhut2, Patil Nikhil3, Payghan Santosh4 1Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar, Panhala, Kolhapur, Maharashtra, India416114 2Department of Pharmaceutics, Ashokrao Mane College of Pharmacy, Peth Vadgaon, Kolhapur, Maharashtra, India416112 3Vasantidevi Patil Institute of Pharmacy, Kodoli, Panhala, Kolhapur, Maharashtra, India416114 4Principal Vasantidevi Patil Institute of Pharmacy, Kodoli, Panhala, Kolhapur, Maharashtra, India416114 *Corresponding Author E-mail: swapnilchopade.tkcp@gmail.com
Abstract The aim of this investigation is to formulate and characterize FDTs Formulations for physicochemical properties like Differential Scanning Calorimetry (DSC) and Fourier Transformed Infra Red Spectroscopy (FTIR) characterized the interactive powder sample mixture. Rapidly disintegrating tablets were formulated by direct compression method. For disintegration time, hardness, friability, tensile strength, weight variation and in vitro release studies, the Fast disintegrating tablets have been evaluated. During the FDT process, FTIR indicated that there was no chemical reaction between the two species (drug and excipients). In all concentrations tested in the fast dissolving tablet formulation, the interactive mixture was found to be effective. In the case of interactive mixing, disintegration time (DT) of less than 30 seconds was observed. In pharmaceutical applications, FDTs can be used as a better option. Top Keywords Tenoxicam, FDTs, Direct compression method, Disintegration time, Differential Scanning Calorimetry, FTIR. Top |