Origin of Cancer Stem Cells-A Short Review Lavanya A.1,*, Shwetha K. N.2, Vanishri H. C.3, Rao Roopa S.4, Dominic A.5, Sowmya S. V.6 1Post Graduate Student, Department of Oral Pathology, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, Bangalore-560054 2Tutor, Department of Oral Pathology, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, Bangalore-560054 3Assitant Professor, Department of Oral Pathology, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, Bangalore-560054 4Professor and Head, Department of Oral Pathology, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, Bangalore-560054 5Assitant Professor, Department of Oral Pathology, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, Bangalore-560054 6Associate Professor, Department of Oral Pathology, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, Bangalore-560054 *Corresponding Author E-Mail: drlavsmdsop92@gmail.com
Online published on 18 January, 2019. Abstract Evidences of the current research say that cancer is multi-factorial with varied mechanisms of origin. Globally, it is the second most dominant factor for human death. Most theories disclosed that either intrinsic (genetic) or extrinsic factors were responsible for the cancer development. The cells being triggered by these factors may be somatic (differentiated functional cell) or a normal stem cell with multi-potency or even the transient proliferative cells derived from the stem cells. These stem cells possess several features like slow cell cycle, ability to extrude chemotherapeutic drugs, exhibit epithelial mesenchymal transition and inhibit apoptosis. It is known to play an important role in cancer progression and recurrence. However, the origin of these cancer stem cells still remains debatable. Top Keywords Cancer Stem Cells, Cell Microenvironment, Tumorigenic. Top |