Intermittent Hypoxia-Hyperoxia exposures Improve Cardiometabolic Profile, Exercise Tolerance and Quality of Life: A Preliminary Study in Cardiac Patients Glazachev Oleg1,*, Susta Davide1,2, Dudnik Elena1, Zagaynaya Elena1 1I.M. Sechenov First Moscow State Medical University, Moscow, Russia 2School of Health and Human Performance, Dublin City University, Dublin, D9, Ireland *Corresponding author: Oleg Glazachev I.M. Sechenov First Moscow State Medical University, Moscow, Russia, E-mail: glazachev@mail.ru kseniabadz@gmail.com
Online published on 7 February, 2018. Abstract Study design: randomized controlled before-and-after and in follow-up trial. Forty-six CAD patients volunteered to take part in the study: a group of 27 patients undertook an Intermittent Hypoxia (O2 at 10%)-Hyperoxia (O2 at 30%) Training (IHHT), while a control group (CTRL) of 19 patients was allocated to sham IHHT treatment (breathing via face mask by room air, O2 at 21%). Exercise performance, blood and metabolic profile, quality of life (MOS SF-36, Seattle Angina Questionnaire, SAQ) were measured before and after IHHT/sham IHHT in both groups; the intervention group was also assessed one month after completing the IHHT. The IHHT intervention group showed improved exercise capacity (+1, 8 ml O2/min/kg, p=0, 02), reduced resting systolic and diastolic blood pressures (151/85 before vs 130/73 after p<0, 01), enhanced Left Ventricle Ejection Fraction (62, 6±5, 5% vs 58±6, 2%, p<0, 01), glycemia was significantly reduced only at 1month follow-up (6, 18±1, 7 after vs 7, 10±2, 34 mmol/l at baseline, p=0, 037). Frequency of angina as reason to stop exercising was significantly reduced after treatment and at 1-month follow-up. In CAD patients an Intermittent Hypoxia-Hyperoxia Training program is associated with improved exercise tolerance, risks factors profile and quality of life (SF-36, SAQ). IHHT has proved to be safe, well tolerable and easily applicable in cardiac patients. Top Keywords Intermittent hypoxia-hyperoxia training, exercise tolerance, cardiometabolic profile, coronaryartery disease, quality of life, cardiac rehabilitation. Top |