The Curative Effect of Ajwa Dates Toward Hyperuricemia Levels in Wistar Rat (Rattus norvegicus) Mallapiang Fatmawaty1, Syarfaini2, Azriful3 1Occupational Health and Safety Section, UIN Alauddin, Makassar 2Nutrition Department, UIN Alauddin, Makassar 3Epidemiology Department, Faculty of Medicine and Health Sciences, UIN Alauddin, Makassar Online published on 7 February, 2018. Abstract Background Hyperuricemia in Indonesia does not only occur in the elderly but also in younger people. objective This study aims to determine the effect of Ajwa dates on blood uric acid levels in Wistar rats (Rattus norvegicus) and to establish the effective dosage. Method The experimental design of this study was pretest-posttest with control group design, using Wistar rats randomized into three experimental groups and a control group. The data was analyzed through paired T-tests, one-way ANOVA, and LCD post hoc tests to show the curative effect of Ajwa dates toward uric acid levels in Wistar rats. Results Ajwa dates showed a significant effect toward decreasing blood uric acid levels in the low-dose (p=0.014 < 0.05), medium-dose (p=0.0006 < 0.05), and high-dose (p=0.0008 < 0.005) groups, while the control group showed a significant increase in blood uric acid levels (p=0.005< 0.05). The one-way ANOVA test indicated a significant in blood uric acid levels between the groups before administering Ajwa dates (0.002 < 0.05) and after administration (0.000 < 0.05). The LSD post hoc test showed significant differences between the high-dose group and low-dose group (0.001 < 0.05) as well as the high-dose group and the middle-dose group (0.008 < 0.05). Conclusion The Ajwa date is effective in the reduction of blood uric acid levels in the Wistar rat (Rattus norvegicus). The high dose (equal to nine grain of Ajwa dates) is the most effective dose in decreasing blood uric acid levels. Top Keywords Curative Effect, Uric Acid, Ajwa Date, Curative, Wistar Rat. Top |