Bacterial and Viral Pathogen spectra of ARI among the Children Below 5 Years Age Group in tribal and Coastal Regions of odisha Biswal Bhagyalaxmi1, Dwibedi Bhagirathi2, Hansa Jagadish3,5, Kar Shantanu Kumar4,* 1PhD Scholar, ICMR-RMRC, Bhubaneswar, India 2Scientist-E, ICMR-RMRC, Bhubaneswar, India 3Scientist-B, Presently at ICMR-RMRIMS, Patna, India 4Director (Research), Directorate of Medical Research, IMS & SUM Hospital, Siksha O Anusandhan University 5Directorate of Medical Research, IMS & SUM Hospital, Siksha O Anusandhan University, Bhubaneswar, India *Corresponding author: Dr Shantanu Kumar Kar Director (Research) medical & life Sciences Directorate of Medical Research, IMS & SUM Hospital, S ‘O ’A University, BBSR Former-Director RMRC, Bhubaneswar Email id-jagadish.hansa@gmail.com; +919437041322
Online published on 7 February, 2018. Abstract Aim The study evaluates the spectra of viruses, bacteria and mix infection of both pathogens and its drug sensitivity pattern in hospitalized children presenting with Acute Respiratory Infections (ARI) in two geographical settings of Odisha, India. Materials and method Nasopharyngeal/Oropharyngial swabs cultured from 1063 ARIs affected children fallowing standard bacteriological culture method & antimicrobial susceptibility using CLSI guidelines and respiratory viruses by multiple reverse transcriptase polymerase chain reaction (RT-PCR). Results Out of 1063 specimens 82.2% exhibited seasonal variation and presence of S. Pneumonia (31%), K. pneumaniae (32%), S. aureus, Streptococcus spp, M. pneumoniae, P. aeruginosa and Moraxilla spp bacterial pathogens. The viruses detected were RSV (12.1%), followed by HPIV-1 (5.6%), Influenza A (4.6%), and HMPV (2.8%). Co-existence of two or more pathogens was found in 116 (10.9%) specimens. Pathogen detection in less than 1-year was significantly higher (P =0.0039). The pathogens isolated in tribal region was significantly higher (52.2%, P<0.0015). Antimicrobial susceptibility indicates the presence of multidrug resistance, extended spectrum betalactamases (ESBL) (75%) and third generation cephalosporin's (87.4%), MRSA (16.6%) and Penicillin resistant S. pneumonia (84.7%). Conclusion The results indicate the need for use of appropriate drug regimens to address ARI in different geographical settings of the state. Top Keywords Infection, Pathogen, ARI. Top |