Pharmacological activities of Curcumin: An update Alabdali Aya Yaseen Mahmood1, Chinnappan Sasikala2,*, Razik Basma M. Abd3, Mogana R2, Khalivulla Shaik Ibrahim2, Rahman H6 1The University of Mashreq, Collage of Pharmacy, Iraq, Baghdad 2Faculty of Pharmaceutical Sciences, UCSI University Kuala Lumpur (South Wing), No. 1, Jalan Menara Gading, UCSI Heights56000Cheras, Kuala Lumpur, Malaysia 3Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, 10001, Baghdad, Iraq 6Department of Pharmaceutics, PSG College of Pharmacy, Peelamedu, Coimbatore - 641004 *Corresponding Author E-mail: sasikala@ucsiuniversity.edu.my
Online Published on 20 February, 2023. Abstract In the past few years, multiple drugs have been produced from traditional raw materials and recent pandemic disease COVID-19 once again research on this matter is being conducted to determine potential therapeutic purposes of different Ayurvedic Indian medicines and herbs. One such medicinal herb is Curcuma longa. Curcumin is strong antioxidant, anti-inflammatory, antispasmodic, antiangiogenic, anti-carcinogenic, as shown by multiple in vitro and in vivo studies. The action of the growth factor receptors is inhibited by curcumin. The anti-inflammatory effect of curcumin is obtained on the cytokines, proteolytic enzymes, eicosanoids, and lipid mediators. The superoxide radicals, nitric oxide and hydrogen peroxide, are sifted by curcumin, while lipid peroxidation is inhibited. Such properties of the compound thus form the foundation for its various therapeutic and pharmacological effects could also hold antiviral properties including COVID-19. The aim of this research is to summarize the updated pharmacological activities of curcumin. Top Keywords Curcumin, Polyphenol, Antioxidant activity, Wound healing, COVID-19 activity. Top |