Alterations in gut microbiome and its association with coronary artery disease Usha V.*, Banduji P.P. Department of Biotechnology (PG), PSGR Krishnammal College for Women, Coimbatore - 641 004, Tamil Nadu, India *Corresponding author Email: usha@psgrkcw.ac.in
Online published on 28 April, 2023. Abstract Coronary Artery Disease (CAD), one of the most prevalent heart diseases, has been caused due to the atherosclerotic plaque buildup in the walls of arteries. Alterations in the gut microbiome, also referred to as 'Gut Dysbiosis' has been previously associated with various diseases including CAD. Several other factors, including lifestyle changes, genetic factors and the environment, also affect the occurrence of CAD. Healthy gut microbial species and their metabolites have been linked with health benefits. Gut microbiome harbour around 1014 micro-organisms which influenced the overall human health. Enterolignans and short chain fatty acids (SCFAs) have been considered as the promising metabolites which reduced the risk of CAD. However, other microbiota derived bioactive metabolites such as trimethylamine (TMA) and trimethylamine N-oxide (TMAO) contributed at a higher level to the progression of CAD, which consequently lead to failure of heart. The present review summarized the beneficial and adverse effects of disruption of gut microbiota in the progression of CAD. Top Keywords Coronary artery disease, Microbiome, Gut microbiome, Gut dysbiosis, Enterolignan, Trimethylamine n-oxide. Top |