Effect of peritoneal dialysis on cyto-biochemical constituents of peritoneal fluid in induced uraemia of dogs Buchoo B. A.1, Parrah J. D.1,*, Moulvi B. A.1, Ganai A. M.1,2,**, Bilal S.1,3 1Division of Veterinary Surgery & Radiology, Faculty of Veterinary Sciences & Animal Husbandry, S.K. University of Agricultural Sciences & Technology, Shuhama, Alusteng, Srinagar, (J&K) - 190 006 2Division of Animal Nutrition, Faculty of Veterinary Sciences & Animal Husbandry, S.K. University of Agricultural Sciences & Technology, Shuhama, Alusteng, Srinagar, (J&K) - 190 006 3Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, S.K. University of Agricultural Sciences & Technology, Shuhama, Alusteng, Srinagar, (J&K) - 190 006 *E-mail: drjdparrah@yahoo.co.in
**E-mail: amganai@rediffmail.com
Abstract Eighteen clinically healthy non-descript male dogs were equally divided into three groups. Uraemia was induced in all the groups by rupture of urinary bladder and post scrotal urethral ligation. The animals of group I, II and III were subjected to cystorraphy and release of post scrotal urethral ligation at 24, 48 and 120 h, respectively, post induction of uraemia followed by intramuscular administration of gentamicin @ 8 mg kg−1 b.w. for 5 days. Normal saline @ 25 ml kg−1 b.w. for 3 days and intraperitoneal dialysis with dialyzing solution (normal saline 1000 ml, inj. gentamicin 267 mg and heparin 5000 i.u.) @ 30 ml kg−1 b.w. for 3 days. Total leucocytic and erythrocytic count of peritoneal fluid significantly increased till terminal stage. With increase of leucocytes there was neutrophilia and monocystosis but lymphocyte percentage decreased. The biochemical analysis of peritoneal fluid showed hypoproteinaemia. Treatment in animals of group I and II at stage 1 and 2 caused return of peritoneal fluid values to normal at the completion of treatment. In group III animals where treatment was delayed, 3 animals died and the rest showed tendency towards normalcy regarding general condition and cyto-biochemical alteration of peritoneal fluid. Top Key words Cyto-biochemical constituents, dialysis, dog, peritoneal fluid, uraemia. Top |