"Immunohistochemical characteristics of patients with macro and giant inactive pituitary tumors" Urmanova Yulduz Makhkamovna1, Bakhtiyarovna Mirtukhtaeva Malika2 1Professor, Doctor of Medical Sciences (DSc), Department of Endocrinology, Pediatric Endocrinology, Tash PMI, Tashkent, Uzbekistan, Email id: yulduz.urmanova@mail.ru 2Endocrinologist, Department of Neuroendocrinology with Pituitary Surgery, RSNPMCCE of the Ministry of Health of the Republic, Uzbekistan Name of Acad. Y.H. Turakulov, Employment Contract, Tashkent, Uzbekistan Online published on 29 June, 2023. Abstract The assessment of the KI-67 and P53 using immunohistochemistry, usually with monoclonal antibodies of MIB1, is mandatory for evaluating proliferation in patients subjected to transnasal adenomectomy of the pituitary gland. Goal To study the prognostic significance of invasion and markers of proliferation in patients with macro and giant inactive pituitary tumors. Material and Methods In total, 272 patients with macro and giant naga were examined. Of the 272 patients with the naga in the study, 151 patients (men and women) took part in the study) Research methods included: 1) general clinical (study of endocrine, neurological statuses), 2) instrumental (perimetry for all colors, eye bottom, visual acuity, 3) ECG, CT/MRI of the Turkish saddle and adrenal glands, 4) ultrasound of the internal and genitals, etc.), 5) hormonal blood tests (STH, IFR-1, LG, FSG, PRL, TSL, ACTH, prolactin, testosterone, estradiol, progesterone, cortisol and immunohymph hand-chemical studies. Results The observed frequency of immune expression of proliferation markers was 40%/50% for P53 (>3+), 50%/60% for Ki-67 (>2+). Tumors with immune expression of at least 2 markers with a high proliferation index were observed in 54% cohorts and regarded as proliferative adenomas. Conclusion Giant inactive pituitary adenomas of the pituitary gland are often accompanied by invasive growth in the surrounding anatomical structures (more than 80% of cases), which is the main factor that limits the radicality of surgical intervention and increases the number of relapses. Top Keywords NFPA, Giant Pituitary Adenomas. Top |