Ecological and hygienic justifications for the use of the new insecticide seller in agriculture Zhumaeva A.A. Bukhara State Medical Institute, Bukhara, Republic of Uzbekistan Online published on 16 November, 2019. Abstract First of all, this is a general hygiene, large-scale, complex and multifaceted problem. To protect cultivated plants from numerous pests and pathogens, as well as from weeds, a significant assortment of chemicals used to control agricultural pests is used. In this regard, and also considering that certain groups of this class are characterized by embryo toxicity, mutagen city, and other manifestations of biological activity (Iskandarov T.I.-2016, Teyvan R. Ya.-2002). When studying the toxic effect and degree of Seller toxicity, 20% of cc took into account the following indicators: animal survival, behavior, general condition, body weight, time about symptoms of intoxication and death of animals. A study of the effect of the drug on the mucous membranes of the eyes of experimental animals made it possible to establish that the drug has an irritating effect on the mucous membranes of the eyes and skin. In order to establish the MPC of the drug in the water of reservoirs, studies were conducted to study the effect of the drug on the organoleptic properties of water and the sanitary regime of water in reservoirs. According to the effect on the organoleptic properties of water (odor), a threshold concentration of 0.04 mg/L has been established. The experiment was performed on white rats. The drug was introduced in the native form into the conjunctival sac of the animal's eye in an amount of 2–3 drops, the second eye served as a control. 1 hour after application, redness and lacrimation were observed in the experimental eye of the animal. 4 hours after application, slight suppuration, blepharospasm was noted. Thus, the study of the toxicity of the drug was carried out according to the methodological manual "Methodology of integrated and accelerated rationing of pesticides in environmental objects." Approved by the Ministry of Health of the Republic of Uzbekistan on April 10, 2014 and No. 8N-P/193 Top Keywords Biological, Integrated, Blepharospasm, Considering. Top |