Synthesis, characterization and antioxidant activity of some new antipyrine derived schiff bases Fatima Mahwish1, Rathna P Bharath Kumar1,*, Priya R Venu1, Kadiri Sunil Kumar2 1Department of Pharmaceutical Chemistry, Anwarul Uloom College of Pharmacy, Telangana, India 2Department of Pharmacology, College of Pharmaceutical Sciences, Dayanand Sagar University, Karnataka, India *Corresponding Author E-mail: bharathpharm@gmail.com
Online Published on 31 August, 2024. Abstract Synthesis, characterization of a series of some new antipyrine derived Schiff bases 5(a-f) have been carried out and evaluated for their antioxidant activity. The newly synthesized compounds were characterized by physical and spectral data. The compounds 5(a-f) were measured for physical parameters and enlisted. The completion of the reaction, the progress of the reaction, and the purity of all newly produced compounds were monitored by TLC. Compounds in series 5(a-f) have yields that vary from 70 to 93%. Based on a review of the literature, there were no antipyrine derivatived Schiff bases reported till now, hence they were synthesized and characterized in this work. It was found that these moieties were useful in the field of pharmaceutical chemistry and that they demonstrated a variety of pharmacological actions. In the current work, six synthetic compounds 5(a-f) were prepared, and characterized by FTIR, 1HNMR and Mass spectroscopy studies. Melting points were determined and TLC was used to verify the purity of each compound. In an effort to produce new therapeutic compounds these compounds are tested for antioxidant properties and reported. Top Keywords Antipyrine, Schiff bases, Antioxidant activity, Synthesis, Characterization. Top |