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Coupling of single-stranded poly-T DNA with small heterocyclic compounds via peptide linkage Sur Souvik* Research and Development Center, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh - 244001, India *Corresponding Author E-mail: drsouvik.engineering@tmu.ac.in
Online Published on 31 August, 2024. Abstract This study introduces a versatile method for coupling single-stranded DNA with small heterocyclic compounds, leveraging the reactivity of amino and carboxylic functional groups. By employing COMU and Collidine, BNIMZ and BNTZA were successfully coupled with poly-T DNA. The conjugation technique was successfully confirmed by high accuracy MALDI-TOF MS. This approach offers a reliable and efficient strategy for constructing DNA-conjugates with tailored properties. Top Keywords Coupling, Solution-phase, Peptide bond, Heterocyclic, Mass spectrometry. Top | | | |
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