Synthesis and Evaluation of Some New Thiazolidinedione Derivatives for Their Antidiabetic Activities Pattan Shashikant R1,*, Prajact Kekare2, Dighe NS1, Bhawar SB4, Ana Nikalje3, Ashwini Pati3, Hole MB1 1Dept. of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar 2Department of Medicinal Chemistry, K.L.E.S.’s College of Pharmacy, Belgaum, 590 010 3Dept. of Pharmaceutical Chemistry, Y B Chavan College of Pharmacy, Aurangabad 4Dept. of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar *Corresponding Author E-mail: shashipattan@yahoo.com
Online published on 13 March, 2013. Abstract A new series of thiazolidinedione derivatives were synthesized by reacting under microwave irradiation. The structures of these compounds were established by means of IR, 1H-NMR and elemental analysis. All the compounds (B1-B9) were screened for antidiabetic activity on albino rats. Most of these compounds have shown significant antidiabetic activity when compared with the standard drug glibenclamide. Top Keywords Thiazolidinedione, antidiabetic activity, microwave assisted synthesis. Top |