Synthetic and Pharmacological Evaluation of Some Pyridine Containing Thiazolidinones Firke SD1,*, Firake BM1, Chaudhari RY2, Patil VR2 1KYDSCT's College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon, (M.S), India 2TVES's College of Pharmacy, Faizpur, Tal. Yawal, Dist. Jalgaon, (M.S), India *Corresponding Author E-mail: sandipfirke@rediffmail.com
Online published on 13 March, 2013. Abstract A series of N’-[3-(aryl/alkyl substituted)-4-oxo-1, 3-thiazolidin-2-ylidene]-2-(pyridine-2-yloxy) acetohydrazides were synthesized using appropriate synthetic route. These compounds were synthesized by their analytical and spectral data. All the newly synthesized compounds were examined for their antidiabetic activity using GOD-POD method on Wistar strain rats. The acute toxicity study (LD50) values of these compounds were determined. The test compounds showed significant antidiabetic activity on evaluation. Top Keywords Thiazolidinone, Pyridine, Antidiabetic activity. Top |