Sodium alginate cross-linked polymeric microbeads for oral sustained drug delivery in hypertension: Formulation and evaluation Kalbhare Shankar B.1,*, Bhandwalkar Mandar J.1, Pawar Rohit K.1, Sagre Abhirup R.2 1Department of Pharmaceutics, YSPM's Yashoda Technical Campus, Faculty of Pharmacy, Wadhe Satara-415001 Dist-Satara (M.S.), India 2Department of Pharmacology, YSPM's Yashoda Technical Campus, Faculty of Pharmacy, Wadhe Satara-415001 Dist-Satara (M.S.), India *Corresponding Author E-mail: kirankal786@gmail.com
Online published on 16 September, 2020. Abstract The Oral controlled drug delivery system represent the most popular form of sustain drug delivery system for the obvious advantages of oral route of drug administration. Such systems release the drug with constant or variable release rates. The oral controlled release system show a typical pattern of drug release in which the drug concentration is maintain in the therapeutic windows for prolonged period of time (sustain release), there by insuring sustained therapeutic action. They are used as single dosage form. λMax of losartan potassium was found to be at 205.3 nm. All formulation of Losartan potassium micro beads showed the particle size between 0.61 to 0.77mm. The lowest % entrapment efficiency was obtained in formulation F1 and highest was found to be formulation F3. The result demonstrated that effect on % entrapment efficiency with in decreasing concentration of sodium alginate. The drug releases of F 1, F 2 and F 3 formulations is found to be 50.2% to 98.52%, 49.21% to 98.23% and 43.21% to 98.52% respectively. Among all formulations, F 3 was show maximum drug release i.e. 98.51% after 12 hr. It was observed that extent of drug release is attributed to the increase in amount of sodium alginate. All the formulation of microbeads produced the optimum swelling ratio in the range 156–267. The minimum swelling ratio of formulation F1 and higher swelling ratio of formulation F3 is observed. Present work involves preparation and evaluation of sustained release of microbeads of losartan potassium employing sodium alginate as natural polymer. The technique employed for microencapsulation of the drug is ion tropic gelatin. Top Keywords Microbeads, Ion tropic Gelation, Nature polymers, Sustained Release, Losartan Potassium. Top |