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Formulation and evaluation of oxcarbazepine sustained release matrix tablets Reddy Y. Krishna*, Nousheen Gazala Department of Pharmaceutics, Nalanda College of Pharmacy, Jawaharlal Nehru Technological University, Hyderabad, Telangana *Corresponding Author E-mail: rajinisuralabs1@gmail.com
Online published on 16 September, 2020. Abstract The aim of the present work is to develop and evaluate sustained release matrix tablets of Oxcarbazepine. Oxcarbazepine use as monotherapy or adjunctive therapy in the treatment of partial seizures in adults with epilepsy and as adjunctive therapy in the treatment of partial seizures in children ages 4–16 with epilepsy. Total 9 formulations were prepared trail batches. The formulation was evaluated for various pre compression and post compression parameters. All the formulations showed compliance with the pharmacopoeia standards. On the basis of evaluated parameters formulation F6 was considered to be best one. Formulation F6 containing polymer Ethyl cellulose showed 98.72% in-vitro drug release profile. The release data for formulation F6 was fitted to various mathematical models like zero order, first order, krosmeyer peppas and Higuchi model. It was observed that drug follows zero order model. Top Keywords Oxcarbazepine, HPMC K-100, Ethyl cellulose, Sodium carboxy methylcellulose. Top | |
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