Immunohistochemical Expression of BCL-2 and P53 in Oral Verrucous Carcinoma Bhargava Manish, Reader, Singh Anil, Professor, Kumar G.S., Principal, Prof. & Head, Kapoor Palvi, Senior Lecturer Address for Correspondence: Dr. Manish Bhargava, Department of Oral Pathology, Manav Rachna Dental college, Faridabad 580 009, Haryana -INDIA Email: drrnanishbhargava@gmail.com
Online published on 1 May, 2012. Abstract Background Deregulation of oncogenes and tumor suppressor genes involved in apoptosis has been associated with tumor development and progression. Aim of the study is to investigate the involvement of apoptosis regulating proteins in oral verrucous carcinoma in Indian patients, primarily associated with chewing tobacco habits. Methods Immunohistochemical expression of Bcl-2 and p53 was examined in 30 cases of oral verrucous carcinoma. Results Of the 30 cases evaluated, bcl-2 immunoreactivity was seen in 16% of cases while p53 was expressed in 70% of the cases. Conclusion The result of our study suggest that p53 plays a role in development/progression of oral verrucous carcinoma while bcl-2 by itself may have IiWe or no role. Top Keywords Verrucous carcinoma, bcl-2, p53, Immunohistochemistry. Top |