Does time restriction feeding reverse the high fat diet induced obesity in Drosophila melanogaster? Al-Maqashah Mohammad S.1,*, Shakunthala V.2, Damini C.S.3 1Ph.D. Research Scholar, Chronobiology Lab, Department of Studies in Zoology, Manasagangothri, University of Mysore, Mysore, Karnataka570005, India. E-mail: msqo2000@yahoo.com 2Associate Professor, Department of Studies in Zoology, Manasagangothri, University of Mysore, Mysore, Karnataka570005, India. E-mail: drshakunthalav2@gmail.com 3Ph.D. Research Scholar, Chronobiology Lab, Department of Studies in Zoology, Manasagangothri, University of Mysore, Mysore, Karnataka570005, India. E-mail: damini.c.s@gmail.com *Corresponding author: V. Shakunthala Associate Professor, Department of Studies in Zoology, Manasagangothri, University of Mysore, Mysore, Karnataka570005, India. E-mail: drshakunthalav2@gmail.com
Online published on 7 July, 2022. Abstract Obesity and its co-morbidity are the most challenging tasks for the current health care system. It is a multifactorial disorder either due to genetic predisposition, high calorie-dense diet, circadian disruption, etc. Circadian disruption is due to people’s altered lifestyle choices have resulted in increased obesity that can be measured in terms of lipid profiles, overweight, and endogenous antioxidant level. As consequence of this increased diabetes and cardiovascular problems among the current generation. The present study is an attempt to understand the importance of disciplined lifestyle and eating at the right time. Many studies in this regard have revealed time-restriction feeding and its benefits. The current study aims to investigate the adverse effects of a high-fat diet on odd-time eating and high-fat diet with that of time-restriction feeding (TRF). To address this problem, we choose Drosophila melanogaster flies that were fed with different food regime as high-fat diet (HFD), a normal diet (ND) as a control, HFD+TRF and ND+TRF. The biochemical assays were used to detect obesity, the stress and TRF normalizes the triglyceride level to reduce endogenous antioxidants in the HFD group was observed and TRF has an effective response to obesity by reducing body adiposity caused by a high-fat diet. Top Keywords Drosophila melanogaster, TRF, HFD, SOD, Catalase. Top |