Low dose metronomic chemotherapy with cyclophosphamide and piroxicam for the management of canine mammary neoplasms Sowbharenya C., Dharmaceelan S.*, Subramanian M., Kumaresan A. Department of Veterinary Surgery and Radiology, Veterinary College and Research Institute, TANUVAS, Namakkal-637 001, Tamil Nadu, India *Corresponding author's e-mail: dharmaceelan@gmail.com
Online published on 16 November, 2019. Abstract A clinical research was undertaken to evaluate the effect of low dose metronomic (LDM) chemotherapy in 18 clinical cases of canine mammary neoplasms (CMN). The cases were randomly divided into three groups each consisting of six animals. Group I was subjected to LDM therapy with cyclophosphamide @ 10 mg/m2 and piroxicam @ 0.3 mg/kg per os for a period of eight weeks pre operatively on alternate days. Group II was subjected to mere surgical excision alone. Group III was subjected to LDM therapy from 10th day following tumour excision for a period of eight weeks as in group I. Effect of LDM therapy was evaluated based on regression of tumour size and the disease free interval. The haematological and biochemical values were evaluated. Among the three groups, Group I showed progressive regression in the disease free interval improving the quality of life. Top Keywords Canine mammary neoplasms, Cyclophosphamide, Low dose metronomic chemotherapy, Piroxicam. Top |