Age-specific peripheral anti-müllerian hormone concentrations in goats (capra hircus) Haldar Avijit1,*, Sachinandan De2, Singh Vinay3, Datta Mrinmoy3, Pal Prasenjit4, Prakash Bukkaraya S.5 ICAR Research Complex for North Eastern Hill Region, Tripura Centre, Agartala, P.O. Lembucherra-799 210, West Tripura, India 1ICAR-Agricultural Technology Application Research Institute (ATARI), Indian Council of Agricultural Research, Bhumi Vihar Complex, Block GB, Sector-III, Salt Lake, Kolkata-700 097, West Bengal, India 2Animal Biotechnology Centre, National Dairy Research Institute, Karnal-132 001, Haryana, India 3ICAR Research Complex for North Eastern Hill Region, Tripura Centre, Agartala, P.O. Lembucherra-799 210, West Tripura, India 4College of Fisheries, Central Agricultural University, Lembucherra-799 210, West Tripura, India 5Indian Council of Agricultural Research, Krishi Bhavan, New Delhi-110 001, India *Corresponding author's e-mail: vetavijit@gmail.com
Abstract Anti-Mullerian hormone (AMH) appears to be the best biochemical-endocrine marker in assessing the age-related decline of the ovarian follicular reserve. There is inadequate information on age-related changes in peripheral AMH concentrations in goats (Capra hircus). The present study thus aimed (i) to investigate the responsiveness of the ovary to gonadotrophin releasing hormone(GnRH) challenge to release plasma AMH into circulation in view of addressing the question whether ovarian secretion of AMH would be affected by gonadotrophic status in goats and (ii) to determine plasma AMH concentrations at different ages in goats (n= 82) using enzyme immune-assay technique. Data on hormonal concentrations in GnRH-treated animals as well as in different ages of animals were analyzed by nonparametric one-way repeated measure ANOVA and one-way ANOVA, respectively. There was no change (P>0.05) of plasma AMH concentrations after GnRH challenge in experimental goats. Plasma AMH concentrations changed significantly (P<0.05) between the mean rank of the related groups over the time (age) in goats. Plasma AMH concentration at 3 months of age was 0.36 ± 0.04 ng/ml and thereafter it started increasing and reached ≥ 2 ng/ml between 3 and 4 years of age and then showed a progressive decline from 5 years of age and reached at 0.30 ± 0.07 ng/ml at 10 years of age. A cubic model was found to be the best fitted model that delineated the change of plasma AMH level with age. Hence, the present study indicated that peripheralAMH concentration could be a useful management tool for the selection of goats in breeding programmes. Top Keywords Age-related change of AMH, Anti-Mullerian hormone, Goats, GnRH challenge. Top |