Comparison of the clinical effects of Prednisolone, Azathioprine and Oligodeoxynucleotide (ODN) applications in experimentally induced endotoxin uveitis in rats Erkal Tuba Özge Yasar1,*, Kiliç Servet1, Hatipoglu Fatih2, Terzi Funda2 Namik Kemal University, Faculty of Veterinary Medicine, Department of Surgery, Degirmenalti Campus, 59030, Suleymanpasa, Tekirdag, Turkey 1Namik Kemal University, Faculty of Veterinary Medicine, Department of Surgery, Degirmenaltı Campus, 59030, Suleymanpasa, Tekirdag, Turkey 2Selcuk University, Faculty of Veterinary Medicine, Department of Pathology, Alaeddin Keykubat Campus, 42003, Selcuklu, Konya, Turkey *Corresponding author's e-mail: dr.tozgeyasar@gmail.com
Abstract Clinical effects and pathological changes of synthetic oligodeoxynucleotide (ODN), prednol (PRD) and azathioprine (AZA) was compared on uveitis treatment in rats. A total of 28 Wistar Albino, female, adult rats were divided into Control (C), PRD, AZA and ODN groups. Uveitis was induced by 176 μg/rat subcutan injection E. coli, LPS and observed in all animals after 48 hours. Then, 0.25 mg/rat/day AZA and 1.25 mg/rat/day of methylprenidolone was administered bygavage in AZA and PRD groups for ten days. In the ODN group, 178 μg/rat ODN was administered IP totally four times. A numerical weight loss was seen in all groups in the course of the infection period, but dropped dramatically in the PRD group during the treatment period. Average value of right and left eye results showed that immunesuppressive effect of Prednol was higher in terms of IOP values compared to others whereas Shirmer test values were the lowest in the post-treatment period. Finally, Prednol was more effective with its immunesuppressive effect resulting in recovery of photophobia, vascularization and oedema in iris vessels. Top Keywords Azathioprine, ODN, Prednol, Rat, Uveitis. Top |