Comparative hypolipidemic efficacy of homeopathic mother tincture Allium Sativa Q, Curcuma Longa Q and statin in normal and cholesterol fed rabbits Anjum Khalid Mahmood1,*, Rasool Fayyaz2, Bhatti Ehsan Mehmood3, Liaquat Samina4, ZubairYousaf Muhammad5, Zahid Shafaq4, Khan Noor2, Yameen Muhammad6 Department of Wildlife and Ecology, University of Veterinary and Animal Sciences, Lahore, Pakistan 1Department of Wildlife and Ecology, University of Veterinary and Animal Sciences, Lahore, Pakistan 2Department of Fisheries and Aquaculture, University of Veterinary and Animal Sciences, Lahore, Pakistan 3Fisheries Research and Training Institute, Manawan, Punjab Fisheries Department, Lahore, Pakistan 4Discipline of Zoology, Faculty of Fisheries and Wildlife, University of Veterinary and Animal Sciences, Lahore, Pakistan 5Department of Biological Sciences, Forman Christian College (A Chartered University), Lahore, Pakistan 6Department of Applied Chemistry and Biochemistry, Government College University, Faisalabad, Pakistan *Corresponding author Email: Khalid.mahmood@uvas.edu.pk
Online published on 30 August, 2019. Abstract Although, lipid lowering drugs regulate the blood serum lipids, they have several reported side effects. Therefore, a substance that is less toxic and yet effective would be beneficial. Here, we compared the antihypercholesterolemic effects of combinations of homeopathic mother tincture (HMT) Allium sativa Q (garlic) and Curcuma longa Q (turmeric), with standard lipid lowering drug statin. For experimentation, a total of 20 rabbits were recruited and divided into four groups with five rabbits (n = 5). Normal saline (NS) group served as control; second group served as high fat diet (HFD) group, third group received Allium sativa Q (garlic) and Curcuma longa Q (turmeric) and HFD (T & G group) while the fourth group received statin and HFD (statin group). At the end of the 8th week, blood was collected to analyze the comparative efficacy of Allium sativa Q, Curcuma longa Q and statin on total cholesterol (TC), low density lipoproteins (LDL), high density lipoproteins (HDL) and triglyceride (TG). Various parameters measured (mg/dl) in HFD rabbits were, TC (291.76±2.2), LDL (244.20±8.3) and triglycerides (243.79±4.3) increased significantly and HDL (32.19±3.3) was reduced to an alarming level as compared to the NS group after eight weeks. TC, LDL and triglycerides level reduced significantly in T& G group while the HDL level increased significantly as compared to HFD. In statin group, TC (148.37±1.2), LDL (76.32 ±3.4) and TG (104.33 ±8.9) decreased while HDL increased (p<0.05) as compared to the HFD after eight weeks. It was therefore concluded that that homeopathic medicine Allium sativa Q and Curcuma longa Q is equally good like statin and can safely be used to regulate the circulating serum lipid profile. Top Keywords Garlic, Homeopathic medicine, Hyperlipidemia, Medicinal Plants, Statin, Turmeric. Top |