Analgesic and isoflurane sparing effect of buprenorphine and butorphanol in cats anaesthetized with midazolam-ketamine-isoflurane Ramakrishnan K.S.1, Dharmaceelan S.2,*, Senthilkumar S.3, Vijayakumar G.4, Rajendran N.5 Department of Veterinary Surgery and Radiology, Veterinary College and Research Institute, Tamil Nadu Veterinary and Animal Sciences University, Namakkal-637 001, Tamil Nadu, India 1Arunachala Animal Sanctuary and Rescue Shelter, Tiruvannamalai, 606 603, India 2Department of Veterinary Surgery and Radiology, Veterinary College and Research Institute, Tirunelveli-627 358, Tamil Nadu, India 3Department of Veterinary Surgery and Radiology, Veterinary College and Research Institute, Orathanad-614 625, Tamil Nadu, India 4Department of Veterinary Clinical Medicine, Veterinary College and Research Institute, Namakkal-637 002, Tamil Nadu, India 5Veterinary College and Research Institute, Namakkal-637 002, Tamil Nadu, India *Corresponding author's e-mail: dharmaceelan@gmail.com
Online published on 30 August, 2019. Abstract A clinical study was conducted in 18 female cats subjected for ovariohysterectomy to access the analgesic and isoflurane sparing effect of buprenorphine and butorphanol in cats anaesthetized with midazolam-ketamine-isoflurane. The cats were divided into three Groups. In Group I, anaesthesia was induced by midazolam (@0.3mg/kg) ketamine (11mg/kg) mixture. In Group II and Group III cats, butorphanol and buprenorphine were administered intramuscularly @ 0.4 mg/kg and 0.01 mg/kg, 15 minutes prior to induction of anaesthesia as in Group I. Anaesthesia was maintained with isoflurane. Inspired fraction of isoflurane (FiISO) and End-tidal isoflurane (ETISO) in percentage were recorded by main stream infrared spectroscopy analysis. The postoperative antinociceptive efficacy of drugs was studied by four point simple descriptive scale (SDS) scoring system. The study on end-tidal isoflurane concentration revealed both buprenorphine and butorphanol had reduced the use of isoflurane when compared to control group and among that butorphanol had a higher isoflurane sparing effect than buprenorphine. The pain score study revealed buprenorphine produced adequate postoperative analgesia when compared to butorphanol. Top Keywords Buprenorphine, Butorphanol, Cat, Isoflurane, Ketamine, Midazolam. Top |