A study of Serum Soluble CD40 Ligand level and its correlation with serum CK-MB and lipid profile in patients with acutecoronary syndrome Manonmani M.1,*, Velu V. Kuzhandai2, Manimekalai K3 1Assistant Professor, Dept. of Biochemistry, Government Sivagangai, Medical College & Hospital, Sivagangai, Tamil Nadu 2Tutor, Department of Biochemistry, Dept. of Pharmacology, Mahatma Gandhi Medical College & Research Institute, Pillaiyarkuppam, Puducherry, India 3Professor & HOD, Dept. of Pharmacology, Mahatma Gandhi Medical College & Research Institute, Pillaiyarkuppam, Puducherry, India *Corresponding Author: Email: dr.manonmani2011@gmail.com
Online published on 2 January, 2019. Abstract Introduction Coronary heart disease is an impairment of heart function due to inadequate blood flow to the heart. It is the most common cause of death worldwide. Serum sCD40L is an inflammatory marker. It is released from the platelets as soon as the onset of the chest pain. It is a strong predictor of cardio vascular risk factor. Objectives To estimate Serum sCD40Ligand, Serum CK-MB, Serum Lipid Parameters, Serum LDH, and Serum AST levels in patients with ACS. Materials and Methods Study group comprised of 50 subjects were admitted in ICCU with ACS. 50 healthy sex and age matched subjects were taken as control groups. Venous blood samples were collected. Serum Soluble CD40Ligand was estimated by ELISA technique, Serum CK-MB estimated by Immunoinhibition method, Serum Lipid profile by enzymatic assay methods. Serum LDH by DKGC method, Serum AST by Modified IFCC method. Results There was significant increase in Serum sCD40L(p<0.0001), Serum TC, Serum TGL, Serum LDL-C, Serum VLDL while significant decrease in the Sr. HDL-C levels in the ACS patients compared to control group. There was no significant change in Sr. LDH levels and Sr. AST levels in ACS patients compared to control group. There was a significant positive correlation between Serum sCD40L and Serum CK-MB, Serum TC, Serum TGL, Serum LDL-C, Serum VLDL and a negative correlation between Serum sCD40L and Serum HDL-C while no significant correlation was found between Serum sCD40L with Serum LDH and Serum AST levels. Conclusion Serum sCD40L can be used as a marker in individuals with Acute Coronary Artery disease. Top Keywords sCD40L, ACS, MI, CK-MB, Lipid Parameters. Top |