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Degradation of Spectrin and band 3 protein Audi Manisha G.* Associate Professor, Dept. of Biochemistry, Goa Medical College, Bambolim-Goa, India *Corresponding Author: Email: manishaaudi@rediffmail.com
Online published on 2 January, 2019. Abstract Oxygen free radicals generated during radiation injury damage human erythrocyte membrane proteins including spectrin and band 3 protein. Results show an appreciable degree of spectrin and band 3 protein loss of about 55–65% due to crosslinking, and proteolysis when sodium dodecyl sulphate polyacrylamide gel electrophoresis carried out on erythrocyte ghosts. Oxidative damage to membrane proteins lead to degradation of its cytoskeletal components. Top Keywords Spectrin, Band 3 protein, Erythrocyte ghosts, Oxygen free radicals. Top | |
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