Study of Candida Albicans in Various Oral Lesions Singh Priyanka1, Bastian TS2, Singh Anil3, Jaiswal Rohit4, Shrivastava Shikha5, Singh Sanjay Kumar6 1Senior Lecturer, Department of Oral and Maxillofacial Pathology, Sardar Patel Post Graduate Institute of Dental & Medical Sciences, Lucknow 2Professor & Head, Department of Oral and Maxillofacial Pathology, MAHE Institute of Dental Sciences, Kerala 3Professor & Head, Saraswati Dental College, Lucknow 4Reader, Department of Oral and Maxillofacial Pathology, Sardar Patel Post Graduate Institute of Dental & Medical Sciences, Lucknow 5Assistant Professor, Dept. of Oral Pathology, RUHS College of Dental Sciences, Jaipur 6Senior Lecturer, Department of Public Health Dentistry, Sardar Patel Post Graduate Institute of Dental & Medical Sciences, Lucknow Online published on 8 October, 2014. Abstract Fungal infections especially Candida albicans in premalignant and malignant lesions when compared to normal mucosa might indicate contribution of these microorganisms in carcinogenesis. Aim To assess frequency of Candida albicans in different oral lesions; to compare results with Control group and to study clinical significance of Candida infection in different oral lesions. Materials and Method Study was performed in Department of Oral Pathology and Microbiology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow (UP). 30 patients for each of above mentioned clinically diagnosed lesions were randomly selected during 2008–2009. Control group of 30 patients {same for each lesion} was selected from patients who had to undergo minor oral surgical procedures. Smears were obtained from selected site and were stained with PAS stain to check for presence or absence of Candida hyphae. Also, incisional biopsy of lesion was performed: one section was stained with H & E stain and other with PAS stain for presence or absence of Candidal hyphae. Results Incidence of Candida albicans positivity in smear was significantly higher in Oral squamous cell carcinoma group as compared to other groups (p<0.05). Conclusion Linear relationship of Candida with transformation of premalignant lesions and conditions to malignant lesions. Top Keywords Candida Albicans, Koilocytes, Carcinogenesis. Top |