Role of Matrix Metalloproteinase Inhibitors and Collagen Cross Linkers in Resin-dentin Bonding Nagpal Rajni1, Singh Shipra2, Singh Payal2, Sharnam Tushar2, Manuja Naveen3 1Professor, Department of Conservative Dentistry and Endodontics, Kothiwal Dental College and Research Centre, Moradabad, Uttar Pradesh 2Postgraduate Student, Department of Conservative Dentistry and Endodontics, Kothiwal Dental College and Research Centre, Moradabad, Uttar Pradesh 3Professor, Department of Pediatric Dentistry, Kothiwal Dental College and Research Centre, Moradabad, Uttar Pradesh Online published on 10 February, 2015. Abstract Mechanical, physical, and functional properties of dental adhesives have been improved as a result of numerous investigations to achieve chemical balance between their hydrophilic and hydrophobic functional components. However degradation of the adhesive-dentin interface, with time, is a major limitation of contemporary simplified adhesive systems. Bond degradation occurs via water sorption, hydrolysis of ester linkages of methacrylate resins, and activation of endogenous dentin matrix metalloproteinases. This review discusses the role of Matrix Metalloproteinase Inhibitors and Collagen Cross Linkers in preserving the resin dentin bond. Top Keywords Adhesion, Matrix metalloproteinases, Collagen cross-linkers, durability. Top |