Comparison of Healing of Bone Defects by Autogenous Platelet Rich Plasma with Hydroxyapatite and Natural Healing in Pediatric Patients Yadav Anurag1,*, Yadav Gunjan2, Verma Yogendra3 1Reader, Deptt. of Oral & Maxillofacial Surgery, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Chaudhary Vihar, Raebareli Road, Lucknow (U.P) 2Reader, Deptt. of Pedodontics, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Chaudhary Vihar, Raebareli Road, Lucknow (U.P) 3Senior Resident, Faculty of Dental Sciences, Deptt. of Oral Pathology, King George Medical University, Lucknow, (U.P) *Address for Correspondence: Dr Anurag Yadav MDS, 3/237, Vikas Khand, Gomti Nagar, Lucknow, U.P.- 226010, Mob.-09450535212, E-mail: atg_007@rediffmail.com
Online published on 10 February, 2015. Abstract Objectives Objective of this prospective study was to evaluate the early new bone formation in bony defects after placement of PRP along with hydroxyapatite and to compare the efficacy and regenerative potential with normal healing in pediatric patients. Method Forty pediatric patients were selected for the study and were randomly divided in group'A’ and ’B’ each consisting 20 patients. Patients were operated for removal of pathologies. PRP was extracted from patients own blood and mixed with hydroxyapatite and placed in defect in all patients of group B while no grafting was done in group A patients. Post operative clinical and radiographic observation was done at 1st, 2nd, 4th, 12th and 18th week. Data analysis was carried out using x2 test. Results Radiographic evaluation indicated accelerated bone healing in all patients where grafting was done when compared with normal healing Conclusion Conclusion on the basis of results emphasizes that the clinical requirement of a bone substitute material which is biocompatible and non-allergic is fulfilled with PRP. Therefore PRP with hydroxyapatite crystals for the management of osseous defects resulted in superior healing when compared to natural healing. Top Keywords Platelet rich plasma [PRP], Bone regeneration, Osseous defects, Osteoinduction, Osteoconduction. Top |