Candida and Oral Lichen Planus-A Case Control Study Samatha K.S.1, Chikkaiah Usha2,*, Bhat Kishoor G3, Byahatti Sujata Mohan4, Ammanagi Renuka5, Tantradi Praveen4 1Assistant Professor, Department of Oral Medicine and Radiology at Sharavathi Dental College & Hospital, Shivamogga, Karnataka, India 2Professor and HOD, Department of Oral Medicine and Radiology at Sharavathi Dental College & Hospital, Shivamogga, Karnataka, India 3Professor, Department of Microbiology and Immunology, M M's N.G. Halgekar Institute of Dental sciences and research centre, Belgaum, Karnataka, India 4Professor, Department of Oral Medicine and Radiology, M M's N.G. Halgekar Institute of Dental sciences and research centre, Belgaum, Karnataka, India 5Professor and HOD, Department of Oral Medicine and Radiology, M M's N.G. Halgekar Institute of Dental sciences and research centre, Belgaum, Karnataka, India *Corresponding Author: Dr. Usha. Chikkaiah, Professor & HOD, Department of Oral Medicine and Radiology at Sharavathi Dental College & Hospital, Shivamogga, Karnataka, India. Phone number-8050583703, E-mail id- cushamds@gmail.com
Online published on 17 July, 2019. Abstract Background The cause of increased oral cancer risk in OLP patients is unknown, although the oral mucosa affected by OLP may be compromised to the extent of being more sensitive to exogenous mutagens in tobacco, alcohol,betel quid and Candida albicans. The purpose of this study was to compare isolate, quantify, speciate the Candidal species in OLP and controls. Method This study included 20 OLP and 20 controls.. A detailed clinical history were recorded. Sample collection was done by scrapping the superficial mucosal layer by using sterile cotton swab wherein candidal colony forming units (CFU) were calculated for estimation of candidal growth, quantification of candidal colony count and to speciate the different species of candida cultured on Sabouraud's dextrose agar (SDA) and CHROM agar. Results In total, 40% OLP patients and 6.7% of controls yielded candidal growth on culture. C.albicans, C.tropicalis, and combination of C.albicans & C.tropicalis were also speciated, even though C.albicans was predominant species isolated. Conclusion OLP is associated with an increased risk of oral cancer and chronic oral C. albicans infection is recognized as an oral cancer risk factor. Hence the aim of this study was undertaken for the evaluation of growth of candida by using sterile cotton swab wherein candidal colony forming units (CFU) were calculated by using SDA. We isolated combination of C.albicans and C.tropicalis by CHROM agar for the first time in the OLP patients. The candidal colonies were higher in the OLP patients than compared to healthy controls. However the candidal carriage in OLP group was not statistically significant when compared with the control group. Top Keywords Oral Lichen Planus (OLP), Candida species, Sabouraud's dextrose agar (SDA) and CHROM agar. Top |