A Role of Estrogen in Etiopathogenesis of Melasma in Female Patients- A Prospective Observational Study in a Tertiary Care Hospital Varma Krishnendra*, Professor, Kumare Kiran, PG Student, Sharma Harsh, Assistant Professor, Sharma Megha RD Gardi Medical College, Ujjain, Madhya Pradesh *Corresponding Author: Email: krishnendra_verma17@yahoo.co.in
Online published on 3 March, 2016. Abstract Background Melasma is a common patchy brown, tan or blue-gray facial skin discoloration usually seen in women in the reproductive years. Aim To study the role of estrogen in etiopathogenesis of melasma in female patients. Objectives To study the estrogen levels and its imbalance in female patients attending Dermatology OPD of C.R.G.H. within 1 year by correlating with the normal levels. Patients and Methods Sixty -six female patients suffering from melasma, between the ages of 15–45 years, were enrolled in the study. Patients were investigated for estrogen levels at any time of their menstrual cycle and estrogen values estimated according to follicular and luteal phase values. Results Amongst the sixty-six patients, there were only 18 (27.3%) patients who had normal values for estrogen while the remaining 48 patients (72.7%) had deranged values (mostly increased). Conclusion Estrogen plays an important role in causation of melasma. Top Keywords Melasma, estrogen, discolouration, reproductive years. Top |