Comparative Study of the Therapeutic efficacy of Cyproterone Acetate + Eflornithine (Topical) and Eflornithine (Topical) alone in the Treatment of Facial Hirsutism Agarwal Sachin1, Kumar Vinay2, Sayal S K3 1Assistant Professor, Department of Dermatology, SMC, Ghaziabad 2Assistant Professor, Department of Anatomy, SIMS, Hapur 3Prof & HOD, Department of Dermatology, SMC, Ghaziabad Online published on 7 October, 2013. Abstract Throughout the history of human civilization, excessive hair growth has been a concern to mankind the object of superstition and mystery, as well as of cosmetic and medical interest. Hirsutism is a common disorder affecting 5–10% of women; Although various modalities of treatment like cosmetic procedures,laser are there but each of them has its own demerits.Since data concerning long term safety and efficacy of the systemic drugs are also lacking, so studies have been conducted using topical agent Eflornithine Hydrochloride. The purpose of this study was to compare the efficacy and safety of Cyproterone acetate + Eflornithine (topical) and Eflornithine (topical) alone in the treatment of Facial Hirsutism. In this randomized comparative double-blind study, 45 patients with facial hirsutism consistent clinically were recruited. Patients were divided into two groups. In group- 1 (23) patients were given eflornithine (13.9%) and cyproterone acetate and In group 2 (22) patients were given topical eflornithine (13.9%)alone. The study showed that cyproterone acetate in combination with topical Eflornithine (13.9% is safe, well tolerated, and effective therapy for facial hirsutism. Top Keywords Facial Hirsutism, Topical Therapy, Eflornithine (Topical -13.9%), Cyproterone Acetate. Top |