Desquamative Gingivitis, Oxidative Stress, and 8-Hydroxydeoxyguanosine (8-OH-dG/8-OxodG): Role and Significance: A Review Bey Afshan1, Kirmani J R Mahira1,*, Moin Shagufta2, Khan Saif1 1Department of Periodontology and Public Health Dentistry, Dr. Ziauddin Ahmad Dental College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India 2Department of Biochemistry, JNMCH, Aligarh Muslim University, Aligarh, Uttar Pradesh, India *Address for Correspondence: Dr. J R Mahira Kirmani, Department of Periodontology and Public Health Dentistry, Dr. Ziauddin Ahmad Dental College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India. Phone: +91-9690832619. E-mail: mahirakirmani@gmail.com
Online published on 10 December, 2018. Abstract Desquamative gingivitis is an oral inflammatory disease that leads to tissue damage. Medical and dental research has been largely remains focused on an individual factor in desquamative gingivitis, for example, microbes or host. Nowadays, good clinical outcomes are obtained in gingival disease control, but effective management of desquamative gingivitis is still critical. The oxidative DNA damages may play an important part in pathogenesis of many chronic conditions including gingival conditions. Oxidative stress can result in DNA damage, including the oxidation of nucleoside. 8-Hydroxydeoxyguanosine is an oxidized stress derivative DNA damage of deoxyguanosine and is one of the major products of DNA oxidation. This review has largely focused on the role of reactive oxygen species in desquamative gingivitis; oxidative species play important roles in the development of much pathology. Top Keywords 8-Hydroxydeoxyguanosine, deoxyguanosine, DNA, gingivitis, oxidative stress. Top |