Evaluation of Calcium, Phosphorus and Vitamin D Level in Different Stages of Pregnancy in East Indian Population Usmani Farhan1, Poonam2, Sinha Manish Kumar1, Haque S. S.3,*, Kumari Rekha3 1Department of Biochemistry, Patna Medical College and Hospital, Patna, Bihar, India 2Department of Obstetrics and Gynecology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India 3Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India *Address for Correspondence: S. S. Haque, Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India. E-mail: sshaq2002@yahoo.co.in
Online published on 10 December, 2018. Abstract Background Vitamin D, serum calcium (Ca) and inorganic phosphorus deficiency during pregnancy is a significant public health problem in many parts of the world. It is associated with an increased risk of pre-eclampsia, gestational diabetes, and preterm births. Approximately, 99% of the Ca and magnesium in the human body is located in the skeleton. Ca is a essential nutrient and mineral consumed in food and supplements. The mineral is stored bones where it is used to promote strength and support changes and growth throughout life. There is also free Ca in blood used by cells during the normal cellular function. The objective of this study was to assess the role of Ca, phosphorous and vitamin D level in pregnant women at different age groups compare to nonpregnant women in East Indian population. Materials and Methods This cross-sectional study was conducted on 180 normal women between 22 and 45 years of age in their first 24–28 weeks of pregnancy and 50 normal nonpregnant women. After 3 months of follow-up, serum levels of vitamin D and Ca and inorganic phosphorous were measured. Written informed consent was obtained from the subjects. Results The mean age of women in the study group was 25.34 ± 5.40 years; while that in the control group was 25.80 ± 5.90 years. The age of study and control groups was matched. The result shows that serum Ca and inorganic phosphorous in pregnant women lower significantly (P < 0.001), especially in the third trimester as compared to controls. However, vitamin-D levels in pregnant women lower significantly (P < 0.001) at all trimester as compared to controls. Conclusion Vitamin D deficiency coupled with Ca and inorganic phosphorous deficiency may found to be highly prevalent in pregnant East Indian women. The decrease in serum vitamin-D, Ca and inorganic phosphorous levels parallels increase in gestational age. This may result from mineral transfer from mother to developing fetus. Top Keywords Calcium, inorganic phosphorous, pregnancy, vitamin D. Top |