Evaluation of toxic effects of Catharanthus Roseus L. extract in Drosophila melanogaster m. with wing contour bioassay Soumya K., Vardhanan Y. Shibu* Department of Zoology, University of Calicut, Calicut University P.O, Malappuram, 673635 *Corresponding author Email: svardhanan@gmail.com
Online published on 23 October, 2018. Abstract An attempt was made to evaluate the toxic effects of Catharanthus roseus extract in Drosophila melanogaster using wing contour bioassay. The battery toxicity assays helped to demonstrate the chemotactic behavioral response of the intoxicated D. melanogaster larvae. Wing contour bioassay results showed that both dose and exposure time governs the toxicity effects in D. melanogaster larvae. The wing traits showed sound variation in lower dose than in 1.5mg/ml. In higher dose the organism refuse to feed the intoxicated medium and fail to move because of the paralyzing action of the C. roseus bioactive compounds. There was a slight decrease in the wing length and width and the vein intersection points showed slight tendency of dextral rotation. Hence the current study results clearly reveals that higher doses of ethnopharmaceuticals can cause a very strong impact which is similar to that of xenobiotics on organisms. Top Keywords Catharanthus roseus, Drosphila larvae, xenobiotics, toxicity, bioassay, anticancer drug, chemotactic, behaviour, wing traits, feeding. Top |