|
|
|
(3.128.94.171)
|
|
Users online: 12043
|
|
|
|
|
|
|
Ijournet
|
|
|
|
|
|
|
Synthesis of Some New Aryl Thiobarbituric Acid Derivatives as Antibacterial and Antifungal Agents Abdullah Asmaa M.1, Ali Zinab Z. Mohammed1, Thani Mohammed Z.1 1Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq Online published on 7 May, 2019. Abstract We report the synthesis of some aryl thiourea derivatives (1and 2) produced through the reaction of aniline derivatives with CS2 in absolute ethanol. These derivatives were condensed with dimethylmalonate or azo derivatives using THF as solvent to obtain thiobarbituric acid derivatives (3 and 4, 11–16). The later compounds (3and4) were reacted with different aldehydes to produce a new series of thiobarbituric derivatives (5–10). The species thus synthesized were characterized using different analytical techniques such as IR and 1HNMR spectroscopies. The activity of the prepared compounds against the growth of certain kind of bacteria such as E.coli, Sepidermidis, Klebseilla, S.aureus and Condida fungi have been investigated, which revealed that all these compounds show good antibacterial and antifungal activity. Top Keywords Aryl thiourea, antibacterial, thiobarbituric acid, antifungal. Top | |
|
|
|
|
║ Site map
║
Privacy Policy ║ Copyright ║ Terms & Conditions ║
|
|
|
746,734,120 visitor(s) since 30th May, 2005.
|
|
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
|
|
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.
|